Well, that's the question that Cinematical is asking. There are plenty of films that could be thought of as "The Graduate of the 2000's". The article can be found here, and it's a great read (one that mentions some of the best movies of the genre that deal with other time periods, like An Education or A Guide To Recognizing Your Saints), but here are some of the films that they mentioned:
The 40 Year Old Virgin
The Squid and the Whale
-What do you think is our generation's best coming-of-age film?